QUANTITATIVE CLINICAL PATHOLOGY

GASTROINTESTINAL DISEASES:

• Intestinal metaplasia of the stomach mucosa
• Gastric dysplasia and carcinoma
• Coeliac disease
• Neuromuscular abnormalities in large intestine

PANCREAS:

• Islet-cell tissue and diabetes
• Cystic fibrosis

LIVER:

Morphometry is useful in diffuse fibrotic liver disease, and has pontential use in the discrimination of hepatocellular carcinoma from cirrhosis and benign focal hepatic lesions.

BREAST:

Morphometric prognostic index of invasive breast carcinoma (tubule formation, nuclear/nucleolar size, mitoses, cell markers).

TESTIS:

Quantitation of spermatogenic activity and tubular morphology in the investigation of infertility.

THYROID:

Morphometry as a prognostic indicator in carcinoma as nuclear size appears to relate to tumour DNA ploidy.

KIDNEY:

Morphometry give an insight into structure and function in glomerular/interstitial diseases, in vascular, connective/tissue and diabetic disease. In various glomerulopathies morphometry can delineating thin basement membrane nephropathy.

URINARY BLADDER:

With his abililty to distinguish grade I and II tumours (fluorescence image analysis, cytometry, DNA cytometry) morphometry can help to creating diagnostic and prognostic aspects.

GYNECOLOGICAL DISEASE:

Quantitation has characterized the histological aspects of CIN. Depth of infiltration and tumours volume are important factors in the therapy and prognosis in cervical and endometrial carcinoma.

RESPIRATORY DISEASE:

Morphometry has given insights into the structure/function relationships in cystic fibrosis, chronic obstructive airways disease and smoking. Tissue quantitation of particles is important in the pneumoconioses.

CARDIOVASCULAR DISEASE:

Quantitative birefrigence measurement on endomyocardial biopsy specimens is a useful technique in addition to the number of circulating activated lymphocytes in the monitoring of cardiac allograft rejection.

NERVOUS SYSTEM DISEASE:

Morphometry is of use in determining nerve fibre damages (demyelinisation, aksonal degeneration) in peripheral neuropathies.

SKIN DISEASE:

Analysis in skin disease has identified changes in dermal elastin with age and in connective-tissue disease. In malignant melanoma the most important measurement in assessing prognosis and therapy is the Breslow thickness or depht of invasion.

BONE HISTOMORPHOMETRY:

Histomorphometrioc data are the key to the diagnosis of metabolic bone disease. The application of histomorphometric techniques are diagnostic in osteoporosis..

MUSCLE DISEASE:

Morphometry are the most important method in evaluating a muscle biopsy specimens.

IMMUNOCYTOCHEMICAL ANALYSIS

CELLS CULTURES

 

OTHERS

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